Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study
Background Human milk (HM) is considered a potential protective factor against bronchopulmonary dysplasia (BPD), but the specific volume needed for its protective effect in mixed feeding is unclear. This study aimed to investigate the impact of different HM volumes on BPD risk.Methods A retrospectiv...
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BMJ Publishing Group
2025-02-01
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| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/9/1/e002727.full |
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| author | Jiaxin Li Chuanzhong Yang Jiaming Yang Huiyan Wang Xueyu Chen Liga ChaoMu Aifen Cao Xiaoyun Xiong |
| author_facet | Jiaxin Li Chuanzhong Yang Jiaming Yang Huiyan Wang Xueyu Chen Liga ChaoMu Aifen Cao Xiaoyun Xiong |
| author_sort | Jiaxin Li |
| collection | DOAJ |
| description | Background Human milk (HM) is considered a potential protective factor against bronchopulmonary dysplasia (BPD), but the specific volume needed for its protective effect in mixed feeding is unclear. This study aimed to investigate the impact of different HM volumes on BPD risk.Methods A retrospective cohort study examined the association between HM volume and BPD risk in very low birthweight (VLBW) infants. Dose-dependent analysis with spline smoothing curve and univariate, multivariate analyses and sensitivity analyses were conducted.Result The study included 339 VLBW infants. BPD incidence was 4.7% (6 infants) in the high HM group (HM volume≥1190 mL), 27.0% (48 infants) in the low HM group (HM volume<1190 mL) and 9.1% (3 infants) in the exclusive formula group, and the difference is statistically significant. Both univariate and multivariate logistic regression analyses showed significantly higher BPD incidence in the low HM group (OR 3.237, 95% CI 0.81 to 12.89) compared with the exclusive formula group. The sensitivity analysis showed that low HM remained a risk factor for BPD (model I OR 3.26, 95% CI 0.92 to 11.53; model II OR 3.28, 95% CI 0.81 to 13.1).Conclusion Higher HM volumes (≥1190 mL) were associated with decreased BPD risk compared with low HM and formula feeding. Although not statistically significant, the low HM group exhibited increased BPD incidence compared with the exclusive formula group. These findings emphasise the importance of considering HM quantity in mixed feeding practices. |
| format | Article |
| id | doaj-art-6334ff25040942c094eac470d55ce0c6 |
| institution | Kabale University |
| issn | 2399-9772 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Paediatrics Open |
| spelling | doaj-art-6334ff25040942c094eac470d55ce0c62025-02-04T17:55:09ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722025-02-019110.1136/bmjpo-2024-002727Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort studyJiaxin Li0Chuanzhong Yang1Jiaming Yang2Huiyan Wang3Xueyu Chen4Liga ChaoMu5Aifen Cao6Xiaoyun Xiong7Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaShenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, ChinaPeking University Cancer Hospital (Inner Mongolia Campus), Hohhot, Inner Mongolia, ChinaShenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, ChinaShenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, ChinaPeking University Cancer Hospital (Inner Mongolia Campus), Hohhot, Inner Mongolia, ChinaShenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, ChinaShenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, ChinaBackground Human milk (HM) is considered a potential protective factor against bronchopulmonary dysplasia (BPD), but the specific volume needed for its protective effect in mixed feeding is unclear. This study aimed to investigate the impact of different HM volumes on BPD risk.Methods A retrospective cohort study examined the association between HM volume and BPD risk in very low birthweight (VLBW) infants. Dose-dependent analysis with spline smoothing curve and univariate, multivariate analyses and sensitivity analyses were conducted.Result The study included 339 VLBW infants. BPD incidence was 4.7% (6 infants) in the high HM group (HM volume≥1190 mL), 27.0% (48 infants) in the low HM group (HM volume<1190 mL) and 9.1% (3 infants) in the exclusive formula group, and the difference is statistically significant. Both univariate and multivariate logistic regression analyses showed significantly higher BPD incidence in the low HM group (OR 3.237, 95% CI 0.81 to 12.89) compared with the exclusive formula group. The sensitivity analysis showed that low HM remained a risk factor for BPD (model I OR 3.26, 95% CI 0.92 to 11.53; model II OR 3.28, 95% CI 0.81 to 13.1).Conclusion Higher HM volumes (≥1190 mL) were associated with decreased BPD risk compared with low HM and formula feeding. Although not statistically significant, the low HM group exhibited increased BPD incidence compared with the exclusive formula group. These findings emphasise the importance of considering HM quantity in mixed feeding practices.https://bmjpaedsopen.bmj.com/content/9/1/e002727.full |
| spellingShingle | Jiaxin Li Chuanzhong Yang Jiaming Yang Huiyan Wang Xueyu Chen Liga ChaoMu Aifen Cao Xiaoyun Xiong Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study BMJ Paediatrics Open |
| title | Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study |
| title_full | Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study |
| title_fullStr | Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study |
| title_full_unstemmed | Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study |
| title_short | Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study |
| title_sort | human milk and bronchopulmonary dysplasia have a dose dependent effect a cohort study |
| url | https://bmjpaedsopen.bmj.com/content/9/1/e002727.full |
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