Trametinib alters contractility of paediatric Noonan syndrome‐associated hypertrophic myocardial tissue slices

Trametinib alters contractility of paediatric Noonan syndrome‐associated hypertrophic myocardial tissue slices

Abstract Aims No curative treatment is available for RASopathy‐associated childhood‐onset hypertrophic cardiomyopathy (RAS‐CM). Preclinical data and individual reports suggest a beneficial effect of small molecules targeting the RAS–mitogen‐activated protein (MAP) kinase (MAPK) pathway in severely a...

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Main Authors: Jules Hamers, Payel Sen, Sarala Raj Murthi, Laura Papanakli, Maria vonStumm, Francesca Baessato, Julie Cleuziou, Christian Meierhofer, Peter Ewert, Andreas Dendorfer, Daphne Merkus, Cordula M. Wolf
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:ESC Heart Failure
Subjects:
cultivation
myocardial slices
Noonan
RAF1
trametinib
Online Access:https://doi.org/10.1002/ehf2.15173
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https://doi.org/10.1002/ehf2.15173

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