Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Coumarin–Triazole–Isatin Hybrids as Selective Butyrylcholinesterase Inhibitors

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Coumarin–Triazole–Isatin Hybrids as Selective Butyrylcholinesterase Inhibitors

A series of 21 novel coumarin–triazole–isatin hybrids was synthesized and evaluated for their potential as multitarget agents in Alzheimer’s disease (AD). The compounds featured variations in alkyl linker length that connects coumarin and triazole and substitution at the 5-position of the isatin rin...

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Bibliographic Details
Main Authors: Aleksandar Dimkovski, Vladimir Dobričić, Milena R. Simić, Maja Jurhar Pavlova, Evgenija Mihajloska, Zoran Sterjev, Ana Poceva Panovska
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
coumarin–trazole–isatin derivatives
Alzheimer’s disease
cholinesterase
hybrid molecules
molecular docking
Online Access:https://www.mdpi.com/1420-3049/30/10/2121
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https://www.mdpi.com/1420-3049/30/10/2121

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