Real time characterization of the MAPK pathway using native mass spectrometry

Abstract The MAPK pathway is a crucial cell-signaling cascade that is composed of RAS, MEK, BRAF, and ERK, which serves to connect extracellular signals to intracellular responses. Over-activating mutations in the MAPK pathway can lead to uncontrolled cell growth ultimately resulting in various type...

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Bibliographic Details
Main Authors: Elena Scott, Sangho D. Yun, Zahra Moghadamchargari, Hanieh Bahramimoghaddam, Jing-Yuan Chang, Tianqi Zhang, Yun Zhu, Jixing Lyu, Arthur Laganowsky
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08028-5
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