Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport

Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport

Nucleoside reverse transcriptase inhibitors (NRTIs) are the backbone of highly active antiretroviral therapy (HAART)—the current standard of care for treating human immunodeficiency virus (HIV) infection. Despite their efficacy, NRTIs cause numerous treatment-limiting adverse effects, including a di...

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Bibliographic Details
Main Authors: John Haynes, Arnav Joshi, Ross C. Larue, Eric D. Eisenmann, Rajgopal Govindarajan
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
NRTI
antiretroviral drugs
antiretroviral toxic neuropathy
HIV-induced neuropathy
peripheral neuropathy
Online Access:https://www.mdpi.com/1999-4923/16/12/1592
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