The Intra-Articular Delivery of a Low-Dose Adeno-Associated Virus-IL-1 Receptor Antagonist Vector Alleviates the Progress of Arthritis in an Osteoarthritis Rat Model

The Intra-Articular Delivery of a Low-Dose Adeno-Associated Virus-IL-1 Receptor Antagonist Vector Alleviates the Progress of Arthritis in an Osteoarthritis Rat Model

<b>Background/Objectives:</b> Interleukin-1 (IL-1) is a pivotal mediator in the pathological progression of osteoarthritis (OA), playing a central role in disease progression. However, the rapid clearance of IL-1 receptor antagonist (IL-1Ra) from the joints may hinder the efficacy of int...

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Main Authors: Shuang Luo, Hao Jiang, Qingwei Li, Shiping Yang, Xuemei Yu, Xiongliang Xu, Qing Xie, Xiao Ke, Qiang Zheng
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
osteoarthritis
gene therapy
adeno-associated virus
IL-1Ra
Online Access:https://www.mdpi.com/1999-4923/16/12/1518
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