Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells

Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells

AIM: To investigate the effects of nintedanib on epithelial-mesenchymal transition (EMT) in cells derived from pterygium, aiming to explore its potential as a pharmacological intervention for pterygium treatment. METHODS: Primary human pterygium epithelial cells (hPEC) and human conjunctival epithel...

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Bibliographic Details
Main Authors:	Ke-Ke Zhang, Meng Li, Yan-Hong Liao, Xiao-Tian Liu, Yong-Bo Bao, Yan Gong
Format:	Article
Language:	English
Published:	Press of International Journal of Ophthalmology (IJO PRESS) 2025-05-01
Series:	International Journal of Ophthalmology
Subjects:	pterygium epithelial-mesenchymal transition nintedanib molecular docking co-immunoprecipitation
Online Access:	http://ies.ijo.cn/en_publish/2025/5/20250503.pdf
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