CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models

CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder characterized by the death of motor neurons in the spinal cord and brain regions, leading to a reduced survival rate in patients. Nearly 20 gene mutations are associated with ALS, with SOD1, FUS, TARDBP, and C9orf72 mutation...

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Main Authors: Hamid Khan, Hammad Riaz, Adeel Ahmed, Mubin Mustafa Kiyani, Sahibzada Muhammad Jawad, Syed Shahab Ud Din Shah, Turki Abualait, Fawaz Al-hussain, Hong-Tao Li, Shahid Bashir
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Regenerative Therapy
Subjects:
Amyotrophic lateral sclerosis (ALS)
CRISPR/Cas9
Cas13
Induced pluripotent cells (iPSCs)
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320425001634
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