SARS-CoV-2 infection promotes lung thrombosis by inducing integrinβ3 expression in vascular endothelial cells

SARS-CoV-2 infection promotes lung thrombosis by inducing integrinβ3 expression in vascular endothelial cells

Abstract Severe COVID-19 shows a high incidence of pulmonary thrombosis. However, the molecular mechanism underlying this phenomenon remains unclear. We have performed RNA sequencing of isolated endothelial cells (ECs) from infected mid-aged and young mice. Compared to young mice, Integrinβ3 (ITGB3)...

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Main Authors: Wataru Ito, Yuya Sakurai, Nako Maishi, Ryo Takeda, Takahito Teshirogi, Li Yu, Yasuhiro Hida, Michihito Sasaki, Yasuko Orba, Takuya Tsumita, Haruhisa Watanabe, Tadahiro Iimura, Terufumi Kubo, Shinsuke Toba, Akihiko Sato, Aya Matsuda, Daisuke Kyuno, Makoto Osanai, Yoichi Ohiro, Toshihiko Torigoe, Hirofumi Sawa, Kyoko Hida
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
SARS-CoV-2
Integrinβ3
Endothelial cells
Thrombosis
Platelets
Online Access:https://doi.org/10.1038/s41598-025-02784-4
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https://doi.org/10.1038/s41598-025-02784-4

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