Proteasome associated function of UCH37 is evolutionarily conserved in Plasmodium parasites

Abstract Ubiquitin C-terminal hydrolase 37 (UCH37 also known as UCHL5) is a conserved deubiquitinating enzyme (DUB) with dual roles in proteasomal degradation and chromatin remodeling in humans. Its Plasmodium falciparum ortholog, PfUCH37, is unusual in that it possesses both DUB and deneddylating a...

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Bibliographic Details
Main Authors: Mohsen Hajisadeghian, Annie M. Geiger, Carla Briggs, Cameron Smith, Katerina Artavanis-Tsakonas
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-80433-y
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