Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase

Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase

Abstract The machinery of mitochondrial DNA (mtDNA) maintenance is only partially characterized and is of wide interest due to its involvement in disease. To identify novel components of this machinery, plus other cellular pathways required for mtDNA viability, we implemented a genome‐wide RNAi scre...

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Bibliographic Details
Main Authors: Atsushi Fukuoh, Giuseppe Cannino, Mike Gerards, Suzanne Buckley, Selena Kazancioglu, Filippo Scialo, Eero Lihavainen, Andre Ribeiro, Eric Dufour, Howard T Jacobs
Format: Article
Language:English
Published: Springer Nature 2014-07-01
Series:Molecular Systems Biology
Subjects:
complex V
DNA replication
mitochondrial biogenesis
mitochondrial DNA
mitophagy
nuclease
Online Access:https://doi.org/10.15252/msb.20145117
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https://doi.org/10.15252/msb.20145117

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