Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

Abstract Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized. In line with previous findings that revealed a role of 5‐HT...

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Main Authors: Coralie Berthoux, Al Mahdy Hamieh, Angelina Rogliardo, Emilie L Doucet, Camille Coudert, Fabrice Ango, Katarzyna Grychowska, Séverine Chaumont‐Dubel, Pawel Zajdel, Rafael Maldonado, Joël Bockaert, Philippe Marin, Carine Bécamel
Format: Article
Language:English
Published: Springer Nature 2020-04-01
Series:EMBO Molecular Medicine
Subjects:
5HT6 receptor
adolescent cannabis abusers
cognitive deficits
mTOR
synaptic transmission
Online Access:https://doi.org/10.15252/emmm.201910605
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https://doi.org/10.15252/emmm.201910605

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