An evolutionarily conserved role for CTNNB1/β-CATENIN in regulating the development of the corpus callosum

An evolutionarily conserved role for CTNNB1/β-CATENIN in regulating the development of the corpus callosum

Summary: The corpus callosum (CC) is a major nerve bundle that connects the two hemispheres of the brain. Dysgenesis of the CC is associated with neurodevelopmental disorders such as the CTNNB1 syndrome. We identified that five individuals carrying CTNNB1 mutations displayed CC deficits. To explore...

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Main Authors: Arpan Parichha, Debarpita Datta, Amrita Singh, Ishita Talwar, Shreya Yadav, Mahima Bose, Varun Suresh, Špela Miroševič, Nina Žakelj, David Gosar, Damjan Osredkar, Shubha Tole
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:iScience
Subjects:
Neuroscience
Molecular neuroscience
Developmental neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225015962
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