RNA demethylase ALKBH5 regulates cell cycle progression in DNA damage response

RNA demethylase ALKBH5 regulates cell cycle progression in DNA damage response

Abstract RNA N6-methyladenosine (m6A) modification plays a crucial role in the DNA damage response, while the detailed mechanisms remain to be explored. In this study, we report the involvement of the m6A demethylase ALKBH5 in X-ray-induced DNA damage response. Depletion of ALKBH5 reduces X-ray-indu...

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Bibliographic Details
Main Authors: Bo Gao, Haitao Pan, Xiaoling Zhou, Lei Yu, Yunyi Gao, Tao Zhang, Xiangwei Gao, Jingyu Hou
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
ALKBH5
DNA damage response
m6A
mRNA stability
Cell cycle
Online Access:https://doi.org/10.1038/s41598-025-01207-8
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https://doi.org/10.1038/s41598-025-01207-8

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