TRIM33 loss reduces androgen receptor transcriptional output and H2BK120 ubiquitination

TRIM33 loss reduces androgen receptor transcriptional output and H2BK120 ubiquitination

Abstract The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number of interacting proteins, many AR coregulators remain to be characterized in relation to th...

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Main Authors: Nils Eickhoff, Janina Janetzko, Nuno Padrão, Sebastian Gregoricchio, Joseph C. Siefert, Liesbeth Hoekman, Simon Linder, Onno Bleijerveld, Andries M. Bergman, Wilbert Zwart
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08449-2
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https://doi.org/10.1038/s42003-025-08449-2

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