Pkd2l1 deletion inhibits the neurogenesis of cerebrospinal fluid-contacting neurons and impedes spinal cord injury repair

Pkd2l1 deletion inhibits the neurogenesis of cerebrospinal fluid-contacting neurons and impedes spinal cord injury repair

Abstract Adult neural stem cells (NSCs) offer a promising avenue for restoring spinal cord injury (SCI). However, their precise identity in the mammalian spinal cord remains unclear. Our previous research demonstrated that Pkd2l1-positive cerebrospinal fluid-contacting neurons (CSF-cNs) possess the...

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Main Authors: Yi Zhang, Liang Cao, Haijian Yan, Zhangrong Luo, Chanjuan Chen, Zeyu Shangguan, Qizhe Li, Xuexing Shi, Leiluo Yang, Wei Tan, Shengxin Yang, Jiangquan Fu, Chunqing Wang, Xiaowei Dou, Qing Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02492-y
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https://doi.org/10.1038/s41420-025-02492-y

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