Inhibition of P-Glycoprotein Asymmetrically Alters the In Vivo Exposure Profile of SGC003F: A Novel Guanylate Cyclase Stimulator

Inhibition of P-Glycoprotein Asymmetrically Alters the In Vivo Exposure Profile of SGC003F: A Novel Guanylate Cyclase Stimulator

As a novel guanylate cyclase stimulator, SGC003F is being developed for the treatment of heart failure with a reduced ejection fraction (HFrEF). This study aimed to assess the effect of P-glycoprotein (P-gp) inhibition on SGC003F exposure in vivo, comparing plasma and tissue levels, and evaluating t...

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Bibliographic Details
Main Authors: Jinle Lou, Nan Li, Xue Jiang, Xu Cai, Lingchao Wang, Xia Wu, Wenpeng Zhang, Chunmei Jin, Xiaomei Zhuang
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Pharmaceuticals
Subjects:
SGC003F
P-gp
drug–drug interactions
tissue distribution
excretion
Online Access:https://www.mdpi.com/1424-8247/17/9/1140
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