PGV-1 Causes Disarrangement of Spindle Microtubule Organization Resulting in Aberrant Mitosis in HLF and HuH6 Cells Associated with Altered MYCN Status

PGV-1 Causes Disarrangement of Spindle Microtubule Organization Resulting in Aberrant Mitosis in HLF and HuH6 Cells Associated with Altered MYCN Status

Purpose: The HLF and HuH-6 cell lines represent hepatocellular carcinoma (HCC) with different characteristics in chromosome content that may give different drug responses. Here, PGV-1 was intended to challenge the growth-suppressing effect on HLF and HuH-6 and trace the molecular target mechanism of...

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Bibliographic Details
Main Authors: Nadzifa Nugraheni, Ummi Maryam Zulfin, Beni Lestari, Novia Permata Hapsari, Muthi Ikawati, Rohmad Yudi Utomo, Yusuke Suenaga, Yoshitaka Hippo, Edy Meiyanto
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-10-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
pgv-1
hcc
mycn
microtubule disarrangement
sorafenib
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-14-665.pdf
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https://apb.tbzmed.ac.ir/PDF/apb-14-665.pdf

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