Integrated network pharmacology, molecular docking, and animal experiments to reveal the potential mechanism of hesperetin on COPD

Integrated network pharmacology, molecular docking, and animal experiments to reveal the potential mechanism of hesperetin on COPD

Abstract Hesperetin (HE), a natural flavonoid exhibiting anti-inflammatory and antioxidant properties, holds significant potential in treating chronic obstructive pulmonary disease (COPD). Nonetheless, the precise mechanisms underlying its effects are yet to be fully elucidated. In this study, we ai...

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Bibliographic Details
Main Authors: Jingxi Wang, Hongyang Wang, Xin Kang, Xiaotian Wang, Xi Li, Jie Guo, Xuan Jing, Xi Chu, Xue Han
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Chronic obstructive pulmonary disease
Hesperetin
Network pharmacology
Molecular docking
MAPKs/NF-κB signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-95810-4
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https://doi.org/10.1038/s41598-025-95810-4

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