Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.

Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.

Triazoles are known for their non-toxicity, higher stability and therapeutic activity. Few nucleoside (L1, L2 and L3) and non-nucleoside 1,2,3-triazoles (L4-L14) were synthesised using click chemistry and they were screened for tumor cell cytotoxicity and proliferation. Among these triazole ligands...

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Main Authors: Jerald Mahesh Kumar, Mohammed M Idris, Gunda Srinivas, Pallerla Vinay Kumar, Vuppalapaty Meghah, Mitta Kavitha, Chada Raji Reddy, Prathama S Mainkar, Biswajit Pal, Srivari Chandrasekar, Narayana Nagesh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0070798
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https://doi.org/10.1371/journal.pone.0070798

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