SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptors

SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptors

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 14 (Nsp14) possesses an N-terminal exonuclease (ExoN) domain that provides a proofreading function for the viral RNA-dependent RNA polymerase and a C-terminal N7-methyltransferase (N7-MTase) domain that meth...

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Bibliographic Details
Main Authors: Naveen Thakur, Poushali Chakraborty, JoAnn M. Tufariello, Christopher F. Basler
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
coronavirus
exonuclease
methyltransferase
Tollip
interferons
virus-host interactions
Online Access:https://journals.asm.org/doi/10.1128/mbio.01071-25
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https://journals.asm.org/doi/10.1128/mbio.01071-25

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