Elucidating of the metabolic impact of risperidone on brain microvascular endothelial cells using untargeted metabolomics-based LC-MS

Elucidating of the metabolic impact of risperidone on brain microvascular endothelial cells using untargeted metabolomics-based LC-MS

Risperidone is useful for the treatment of schizophrenia symptoms; however, it also has side effects, and an overdose can be harmful. The metabolic effects of risperidone at high therapeutic doses and its metabolites have not been elucidated. Endogenous cellular metabolites may be comprehensively an...

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Main Authors: Surachai Ngamratanapaiboon, Napatarin Srikornvit, Patipol Hongthawonsiri, Krittaboon Pornchokchai, Siriphattarinya Wongpitoonmanachai, Jiajun Mo, Petchlada Pholkla, Pracha Yambangyang, Phichanan Duchda, Jenyuk Lohwacharin, Watcharaporn Devakul Na Ayutthaya
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Toxicology Reports
Subjects:
Untargeted metabolomics
Liquid chromatography-mass spectrometry
Brain microvascular endothelial cells
Risperidone
Online Access:http://www.sciencedirect.com/science/article/pii/S221475002400074X
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