Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy

IntroductionEnalapril is an angiotensin-converting enzyme (ACE) inhibitor (ACEi) which is widely used in the management of (paediatric) hypertension and heart failure (HF). There is a significant interindividual variability in the patient's response to enalapril that is not completely understoo...

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Main Authors: N. J. L. Smeets, I. N. van Hoek, J. J. M. Jans, M. Dalinghaus, S. Laer, M. Bajcetic, C. Male, S. N. de Wildt
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pediatrics
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Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1530063/full
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