Optimizing muscle mass and function in advanced lung cancer patients: randomized, double-blind, placebo-controlled trial protocol using High Eicosapentaenoic acid and PROtein (HEPRO) to modulate epigenetics, reduce toxicity and improve gut microbiota

Optimizing muscle mass and function in advanced lung cancer patients: randomized, double-blind, placebo-controlled trial protocol using High Eicosapentaenoic acid and PROtein (HEPRO) to modulate epigenetics, reduce toxicity and improve gut microbiota

Background Lung cancer is strongly associated with malnutrition and detrimental changes in muscle mass (MM), which can lead to reduced quality of life and reduced tolerance to and efficacy of antineoplastic treatment. The loss of MM and myosteatosis (fat infiltration into muscle) have been linked to...

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Main Authors: Imanuely Borchardt, Carla Prado, Tatiane Montella, Gisele Fraga Moreira, Gisele Farias, Marina Xavier Reis, Fernanda Taveira, Fernanda Carneiro Dias, Pedro De Marchi, Alberto Davalos, Carolina Alves Costa Silva, Carlos GilMoreira Ferreira, Andreia Melo, Wilza Peres
Format: Article
Language:English
Published: PeerJ Inc. 2025-06-01
Series:PeerJ
Subjects:
Lung cancer
Omega 3
Body composition
Muscle function
Gut microbiota
MicroRNA
Online Access:https://peerj.com/articles/19506.pdf
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