Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients.

Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients.

Fetal haemoglobin (HbF) is a major ameliorating factor in sickle cell disease. We investigated if a quantitative trait locus on chromosome 6q23 was significantly associated with HbF and F cell levels in individuals of African descent. Single nucleotide polymorphisms (SNPs) in a 24-kb intergenic regi...

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Main Authors: Lisa E Creary, Pinar Ulug, Stephan Menzel, Colin A McKenzie, Neil A Hanchard, Veronica Taylor, Martin Farrall, Terrence E Forrester, Swee Lay Thein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004218&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004218&type=printable

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