Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transitions that remain to be structurally and mechanistic...

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Main Authors: Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby H P Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda A K Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1002049&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1002049&type=printable

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