Cirsiliol alleviates experimental inflammatory bowel disease via restoration of intestinal barrier integrity and inhibition of NF-κB and MAPK pathways

Cirsiliol alleviates experimental inflammatory bowel disease via restoration of intestinal barrier integrity and inhibition of NF-κB and MAPK pathways

Abstract Inflammatory bowel disease (IBD) involves chronic gut inflammation and barrier damage. While natural flavonoids show promise for IBD treatment, cirsiliol’s effects were unknown. This study examined cirsiliol’s therapeutic potential in mice with DNBS-induced colitis and its mechanisms in vit...

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Bibliographic Details
Main Authors: Juan Gao, Haiyang Li, Zhenquan Wang, Gufen Jiang, Liao Pan, Zhengxuan Jiang, Xiaohong Lei
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Inflammatory bowel disease
Cirsiliol
Flavonoid
Intestinal barrier
Pathway
Online Access:https://doi.org/10.1038/s41598-025-09896-x
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https://doi.org/10.1038/s41598-025-09896-x

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