AKR1C3 mediates gastric cancer cell invasion and metastasis via the AKT and JNK/p-NF-κB signaling pathways

AKR1C3 mediates gastric cancer cell invasion and metastasis via the AKT and JNK/p-NF-κB signaling pathways

Abstract Gastric cancer (GC) is globally recognized as the fifth most common cancer and the third leading cause of cancer-related mortality. Early metastasis in GC significantly contributes to its high mortality and unfavorable prognosis. However, the underlying mechanisms of this phenomenon remain...

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Bibliographic Details
Main Authors: Liying Lin, Xinzhu Xiao, Xiaoxiong Guo, Canmei Zhong, Mingkai Zhuang, Jie Xu, Yin Wang, Fenglin Chen
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
AKR1C3
Gastric cancer
EMT
AKT
JNK
NF-κB
Online Access:https://doi.org/10.1038/s41598-024-82039-w
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https://doi.org/10.1038/s41598-024-82039-w

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