Meta-analysis of the accuracy of CD64, HBP, and PCT in differential diagnosis of sepsis patients
Introduction: The aim of this study was to systematically evaluate the accuracy of the cluster of differentiation 64 (CD64) molecule, heparin binding protein (HBP), and procalcitonin (PCT) in the differential diagnosis of sepsis patients. Methodology: Literature in multiple Chinese and English da...
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The Journal of Infection in Developing Countries
2025-05-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/20063 |
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| author | Bin Qiu Jianjiang Huang Fang Zhang Yuyu Wang |
| author_facet | Bin Qiu Jianjiang Huang Fang Zhang Yuyu Wang |
| author_sort | Bin Qiu |
| collection | DOAJ |
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Introduction: The aim of this study was to systematically evaluate the accuracy of the cluster of differentiation 64 (CD64) molecule, heparin binding protein (HBP), and procalcitonin (PCT) in the differential diagnosis of sepsis patients.
Methodology: Literature in multiple Chinese and English databases were searched to screen for CD64, PCT, and HBP related studies that focused on the differential diagnosis of sepsis. The literature was reviewed to extract the true positive, false positive, true negative, and false negative data; and STATA 17.0 software was used to combine the sensitivity, specificity, and area under the sensitivity receiver operating characteristic curve (SROC) of CD64, PCT, and HBP.
Results: This study included 17 articles. The combined sensitivity of CD64, HBP, and PCT were 0.87 [0.73~0.94], 0.85 [0.71~0.93], and 0.86 [0.64~0.96], respectively. The combined specificity of CD64, HBP, and PCT were 0.87 [0.78~0.93], 0.80 [0.06~1.00], and 0.63 [0.23~0.91], respectively; and all showed significant heterogeneity. There was a significant change in diagnostic odds ratio (DOR) values after excluding individual studies. The DOR value was overestimated when the sample size was small. The specificity of research in China was relatively low.
Conclusions: CD64, HBP, and PCT are all useful in the diagnosis of sepsis; and further optimization of diagnostic thresholds is needed before clinical application to improve the quality of testing. A prospective study with larger sample size is needed to improve the reliability of meta-analysis results.
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| format | Article |
| id | doaj-art-61b6942d9adb4f93afa9f1f47b78d7d5 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-61b6942d9adb4f93afa9f1f47b78d7d52025-08-20T03:22:30ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802025-05-01190510.3855/jidc.20063Meta-analysis of the accuracy of CD64, HBP, and PCT in differential diagnosis of sepsis patientsBin Qiu0Jianjiang Huang1Fang Zhang2Yuyu Wang3Intensive Care Unit, Shengzhou People's Hospital, Shaoxing, 312400, ChinaIntensive Care Unit, Shengzhou People's Hospital, Shaoxing, 312400, ChinaIntensive Care Unit, Shengzhou People's Hospital, Shaoxing, 312400, ChinaIntensive Care Unit, Shengzhou People's Hospital, Shaoxing, 312400, China Introduction: The aim of this study was to systematically evaluate the accuracy of the cluster of differentiation 64 (CD64) molecule, heparin binding protein (HBP), and procalcitonin (PCT) in the differential diagnosis of sepsis patients. Methodology: Literature in multiple Chinese and English databases were searched to screen for CD64, PCT, and HBP related studies that focused on the differential diagnosis of sepsis. The literature was reviewed to extract the true positive, false positive, true negative, and false negative data; and STATA 17.0 software was used to combine the sensitivity, specificity, and area under the sensitivity receiver operating characteristic curve (SROC) of CD64, PCT, and HBP. Results: This study included 17 articles. The combined sensitivity of CD64, HBP, and PCT were 0.87 [0.73~0.94], 0.85 [0.71~0.93], and 0.86 [0.64~0.96], respectively. The combined specificity of CD64, HBP, and PCT were 0.87 [0.78~0.93], 0.80 [0.06~1.00], and 0.63 [0.23~0.91], respectively; and all showed significant heterogeneity. There was a significant change in diagnostic odds ratio (DOR) values after excluding individual studies. The DOR value was overestimated when the sample size was small. The specificity of research in China was relatively low. Conclusions: CD64, HBP, and PCT are all useful in the diagnosis of sepsis; and further optimization of diagnostic thresholds is needed before clinical application to improve the quality of testing. A prospective study with larger sample size is needed to improve the reliability of meta-analysis results. https://jidc.org/index.php/journal/article/view/20063CD64HBPPCTsepsisdiagnosis |
| spellingShingle | Bin Qiu Jianjiang Huang Fang Zhang Yuyu Wang Meta-analysis of the accuracy of CD64, HBP, and PCT in differential diagnosis of sepsis patients Journal of Infection in Developing Countries CD64 HBP PCT sepsis diagnosis |
| title | Meta-analysis of the accuracy of CD64, HBP, and PCT in differential diagnosis of sepsis patients |
| title_full | Meta-analysis of the accuracy of CD64, HBP, and PCT in differential diagnosis of sepsis patients |
| title_fullStr | Meta-analysis of the accuracy of CD64, HBP, and PCT in differential diagnosis of sepsis patients |
| title_full_unstemmed | Meta-analysis of the accuracy of CD64, HBP, and PCT in differential diagnosis of sepsis patients |
| title_short | Meta-analysis of the accuracy of CD64, HBP, and PCT in differential diagnosis of sepsis patients |
| title_sort | meta analysis of the accuracy of cd64 hbp and pct in differential diagnosis of sepsis patients |
| topic | CD64 HBP PCT sepsis diagnosis |
| url | https://jidc.org/index.php/journal/article/view/20063 |
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