Immune signaling mediates stromal changes to support epithelial reprogramming in celiac duodenum

Immune signaling mediates stromal changes to support epithelial reprogramming in celiac duodenum

Summary: Celiac disease is a chronic autoimmune disorder affecting 0.5%–1% of the population. Here, we assembled the most comprehensive single-cell RNA sequencing (scRNA-seq) dataset in celiac disease (CeD) to date, including 203,555 cells across 21 active CeD and 11 control duodenal samples. CeD wa...

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Main Authors: Dylan Richards, Klebea Sohn, Shrikanth Chomanahalli Basavarajappa, Daniel Horowitz, Joshua Rusbuldt, Lynn Tomsho, Kate Paget, Ivan Chavez, Koen Van den Berge, Brad McRae, Heather Loughnane, Seamus Hussey, Patrick Walsh, Darren Ruane
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008101
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http://www.sciencedirect.com/science/article/pii/S2211124725008101

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