Clinical validity of dried blood spot assay for the measurement of functional C1 inhibitor in angioedema due to C1 inhibitor deficiency

Clinical validity of dried blood spot assay for the measurement of functional C1 inhibitor in angioedema due to C1 inhibitor deficiency

Background: Functional C1 inhibitor (fC1INH) is a key biomarker for the diagnosis of hereditary angioedema due to C1 inhibitor (C1INH) deficiency. A novel fC1INH assay from dried blood spot (DBS) reduces practical fC1INH testing limitations versus conventional fC1INH assays, but its sensitivity and...

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Bibliographic Details
Main Authors: Jonathan A. Bernstein, MD, Jie Cheng, PhD, Thomas Pisani, MSc, Dan Sexton, PhD, Rachel E. Whitaker, PhD, Daniel Nova Estepan, PharmD, RPh, Neil Inhaber, MD
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
Assay
diagnostics
functional C1 inhibitor
hereditary angioedema
Online Access:http://www.sciencedirect.com/science/article/pii/S2772829325000025
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