Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model

Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model

Abstract Background Traumatic brain injury (TBI) is a major cause of disability and mortality among children and adults in developed countries. Transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2) has antioxidant, anti-inflammatory and neuroprotective effects and is closely related...

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Bibliographic Details
Main Authors: Zigui Chen, Chunyuan Zhang, Yuhua Fang, He Zhang, Jiawei Luo, Changfeng Miao, Jiale Li, Jun Peng, Yingqi Qiu, Ying Xia, Qisheng Luo
Format: Article
Language:English
Published: BMC 2025-02-01
Series:European Journal of Medical Research
Subjects:
Olfactory mucosa-mesenchymal stem cells
Traumatic brain injury
Nuclear factor erythroid-derived 2-like 2
Angiogenesis
Microglia
Online Access:https://doi.org/10.1186/s40001-025-02344-6
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