Role of Central Nervous System Prophylaxis in Primary Testicular Diffuse Large B-cell Lymphoma in Reducing Risk of Central Nervous System Relapse: A Systematic Review and Meta-analysis

Role of Central Nervous System Prophylaxis in Primary Testicular Diffuse Large B-cell Lymphoma in Reducing Risk of Central Nervous System Relapse: A Systematic Review and Meta-analysis

BACKGROUND: Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is associated with a significant risk of central nervous system (CNS) relapse. CNS prophylaxis strategies, such as high-dose methotrexate (HD-MTX) and intrathecal (IT) chemotherapy, are commonly implemented, though their effecti...

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Bibliographic Details
Main Author: Salem Bahashwan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:Journal of Applied Hematology
Subjects:
central nervous system
high-dose methotrexate
intrathecal chemotherapy
prophylaxis
testicular lymphoma
Online Access:https://journals.lww.com/10.4103/joah.joah_58_25
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