MAGED2 Enhances Expression and Function of NCC at the Cell Surface via cAMP Signaling Under Hypoxia

MAGED2 Enhances Expression and Function of NCC at the Cell Surface via cAMP Signaling Under Hypoxia

Mutations in <i>MAGED2</i> cause transient antenatal Bartter syndrome (tBS) characterized by excessive amounts of amniotic fluid due to impaired renal salt transport via <i>NKCC2</i> and NCC, high perinatal mortality, and pre-term birth. Surprisingly, renal salt handling comp...

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Bibliographic Details
Main Authors: Aline Radi, Sadiq Nasrah, Michelle Auer, Aparna Renigunta, Stefanie Weber, Elie Seaayfan, Martin Kömhoff
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
<i>MAGED2</i>
NCC
Bartter syndrome
protein trafficking
endocytosis
exocytosis
Online Access:https://www.mdpi.com/2073-4409/14/3/175
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