Therapeutic potential of isoproterenol in androgenetic alopecia: activation of hair follicle stem cells via the PI3K/AKT/β-Catenin signaling pathway

Therapeutic potential of isoproterenol in androgenetic alopecia: activation of hair follicle stem cells via the PI3K/AKT/β-Catenin signaling pathway

Abstract Background Androgenetic alopecia (AGA) is characterized by the depletion or dormancy of hair follicle stem cells (HFSCs), leading to hair thinning and miniaturization. Reactivating the dormant HFSCs is a promising therapeutic approach. Adrenergic β2 receptor (ADRB2) activation has been show...

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Main Authors: Jiarui Zhang, Jinxing Peng, Zhexiang Fan, Hailin wang, Lihong Wen, Yong Miao, Yu Chai, Zhiqi Hu, Ruosi Chen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Isoproterenol
Hair follicle stem cell
PI3K/AKT/β-catenin signaling
Androgenetic alopecia
Clinical trial
Hair regrowth
Online Access:https://doi.org/10.1186/s13287-025-04418-y
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https://doi.org/10.1186/s13287-025-04418-y

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