The effect of cysteine oxidation on conformational changes of SARS-CoV-2 spike protein using atomistic simulations

Abstract The SARS-CoV-2 Spike (S) protein plays a central role in viral entry into host cells, making it a key target for therapeutic interventions. Oxidative stress, often triggered during viral infections, can cause oxidation of cysteine in this protein. Here we investigate the impact of cysteine...

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Bibliographic Details
Main Authors: Maryam Ghasemitarei, Hoda Taeb, Tayebeh Ghorbi, Maksudbek Yusupov, Tapio Ala-Nissila, Annemie Bogaerts
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-90918-z
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