Sipeimine reduces ethanol-induced gastric ulcer in mice by suppressing Jak-Stat activation and restoring gut microbiota balance

Sipeimine reduces ethanol-induced gastric ulcer in mice by suppressing Jak-Stat activation and restoring gut microbiota balance

Abstract Long-term excessive alcohol intake can directly injure the gastroduodenal mucosa, causing gastric erosions, gastric ulcers, and gastrorrhagia. Fritillaria ussuriensis Maxim is a famous traditional Chinese medicine and health food produced in China. Sipeimine is an alkaloidal component of Fr...

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Bibliographic Details
Main Authors: Xia Yang, Yue Li, Bing Bai, Qinlei Fan, Fei Liu, Shimin Xie, Yaru Li, Xiao Li, Jicheng Han, Yiquan Li, Guangze Zhu, Yilong Zhu, Ningyi Jin
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Sipeimine
Gastric ulcer
Jak-stat pathway
Th17/Treg cell balance
Gut-gastro microbiota
Online Access:https://doi.org/10.1038/s41598-025-12050-2
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https://doi.org/10.1038/s41598-025-12050-2

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