Enhanced engraftment and immunomodulatory effects of integrin alpha-2-overexpressing mesenchymal stromal cells in lipopolysaccharide-induced acute lung injury

Enhanced engraftment and immunomodulatory effects of integrin alpha-2-overexpressing mesenchymal stromal cells in lipopolysaccharide-induced acute lung injury

Abstract Background Human mesenchymal stromal cells (MSCs) have potential as a treatment for inflammatory diseases, including acute lung injury (ALI), due to their anti-inflammatory and immunomodulatory properties. However, their clinical efficacy is often limited by poor post-transplant survival an...

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Main Authors: Hana Kang, Ok-Hyeon Kim, Eun Seo Chang, Jinho Kim, Ji-Young Kim, Geun-Seup Shin, Chul-Hong Kim, Younghyun Lim, Young-Jin Seo, Jung-Woong Kim, Hyun Jung Lee
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Acute lung injury (ALI)
Integrin alpha 2 (ITGA2)
Mesenchymal stromal cells (MSCs)
Immunomodulation
Cell therapy
Online Access:https://doi.org/10.1186/s13287-025-04423-1
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https://doi.org/10.1186/s13287-025-04423-1

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