Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system

Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system

The cardiac conduction system (CCS) orchestrates the electrical impulses that enable coordinated contraction of the cardiac chambers. The T-box transcription factors TBX3 and TBX5 are required for CCS development and associated with overlapping and distinct human CCS diseases. We evaluated the coord...

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Bibliographic Details
Main Authors: Ozanna Burnicka-Turek, Katy A Trampel, Brigitte Laforest, Michael T Broman, Xinan H Yang, Zoheb Khan, Eric Rytkin, Binjie Li, Ella Schaffer, Margaret Gadek, Kaitlyn M Shen, Igor R Efimov, Ivan P Moskowitz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
Tbx3
Tbx5
T-box transcriptional factors
cardiac conduction system (CCS)
ventricular conduction system (VCS)
Tbx3:Tbx5 double-conditional mouse line
Online Access:https://elifesciences.org/articles/102027
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https://elifesciences.org/articles/102027

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