Nanopore full length 16S rRNA gene sequencing increases species resolution in bacterial biomarker discovery

Nanopore full length 16S rRNA gene sequencing increases species resolution in bacterial biomarker discovery

Abstract Discovery of disease-related bacterial biomarkers could be a useful approach for early prevention or diagnosis of various afflictions, such as colorectal cancer. This typically involves analyzing small regions of the 16S rRNA gene (e.g. V3V4) through short-read technologies like Illumina, o...

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Main Authors: Pablo Aja-Macaya, Kelly Conde-Pérez, Noelia Trigo-Tasende, Elena Buetas, Mohammed Nasser-Ali, Paula Nión, Soraya Rumbo-Feal, Susana Ladra, Germán Bou, Álex Mira, Juan A. Vallejo, Margarita Poza
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Illumina
Oxford Nanopore
Colorectal cancer
16S rRNA
Biomarkers
Gut microbiome
Online Access:https://doi.org/10.1038/s41598-025-10999-8
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https://doi.org/10.1038/s41598-025-10999-8

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