Age-targeted vaccination for reducing Clostridioides difficile infection in England: a coupled mathematical-economic modelling analysis

Age-targeted vaccination for reducing Clostridioides difficile infection in England: a coupled mathematical-economic modelling analysis

Abstract Background Clostridioides difficile infection (CDI) is associated with high morbidity and mortality, emphasising the need for prophylaxis. The lead vaccine candidate recently demonstrated promising reductions in medically attended cases. Methods Key risk factors for CDI were incorporated in...

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Bibliographic Details
Main Authors: Laith Yakob, Kasim Allel, Aiman Elragig, Tim Planche, Tendai Mugwagwa, Jennifer C. Moïsi, Holly Yu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Transmission dynamics
C. difficile
Vaccine
QALY
Disease control
Health economics
Online Access:https://doi.org/10.1186/s12916-025-04265-x
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https://doi.org/10.1186/s12916-025-04265-x

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