SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism

SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism

Abstract Purpose Hepatoblastoma (HB) is the most common and lethal malignant solid tumor of liver in children. Targeting the progression of tumor glucose metabolism represents a promising strategy to attenuate the tumor promoting microenvironment. The Warburg effect, a hallmark metabolic feature of...

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Bibliographic Details
Main Authors: Pengxiang Yu, Jiarong Li, Wei Feng, Tao Lei, Wen Jia, Yun He, Yang Bi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Hepatoblastoma
SKP2
IDH1
Glucose metabolism
Glycolysis
Online Access:https://doi.org/10.1186/s12885-025-14644-5
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https://doi.org/10.1186/s12885-025-14644-5

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