CRISPR/Cas9-editing of PRNP in Alpine goats

CRISPR/Cas9-editing of PRNP in Alpine goats

Abstract Misfolding of the cellular PrP (PrPc) protein causes prion disease, leading to neurodegenerative disorders in numerous mammalian species, including goats. A lack of PrPc induces complete resistance to prion disease. The aim of this work was to engineer Alpine goats carrying knockout (KO) al...

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Main Authors: Aurélie Allais-Bonnet, Christophe Richard, Marjolaine André, Valérie Gelin, Marie-Christine Deloche, Aurore Lamadon, Gwendoline Morin, Béatrice Mandon-Pépin, Eugénie Canon, Dominique Thépot, Johann Laubier, Katayoun Moazami-Goudarzi, Ludivine Laffont, Olivier Dubois, Thierry Fassier, Patrice Congar, Olivier Lasserre, Tiphaine Aguirre-Lavin, Jean-Luc Vilotte, Eric Pailhoux
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Veterinary Research
Subjects:
PRNP gene
PRION protein
goat
animal health
embryo editing
knockout
Online Access:https://doi.org/10.1186/s13567-024-01444-1
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