CRISPR/Cas9-editing of PRNP in Alpine goats
Abstract Misfolding of the cellular PrP (PrPc) protein causes prion disease, leading to neurodegenerative disorders in numerous mammalian species, including goats. A lack of PrPc induces complete resistance to prion disease. The aim of this work was to engineer Alpine goats carrying knockout (KO) al...
Saved in:
Main Authors: | , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2025-01-01
|
Series: | Veterinary Research |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13567-024-01444-1 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|