Cyclosporine and Herbal Supplement Interactions

Cyclosporine (CyA) is a well-known immunosuppressant with a narrow therapeutic window. Its bioavailability is affected by many other traditional drugs and herbal extracts. Cytochrome P-450 isoenzymes CYP3A4 and CYP3A5 and protein P-glycoprotein (P-gp) are involved in CyA bioavailability. Interaction...

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Bibliographic Details
Main Authors: D. Colombo, L. Lunardon, G. Bellia
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2014/145325
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