Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models

Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models

Sepsis is a life-threatening organ failure resulting from a poorly regulated infection response. Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. Although experimental studies correlated...

Full description

Saved in:
Bibliographic Details
Main Authors: Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Pharmacological Research
Subjects:
Sepsis
Excretory liver dysfunction
Immune response
PKC-alpha
Midostaurin
AML
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000064
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items