Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models

Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models

Sepsis is a life-threatening organ failure resulting from a poorly regulated infection response. Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. Although experimental studies correlated...

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Main Authors: Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Pharmacological Research
Subjects:
Sepsis
Excretory liver dysfunction
Immune response
PKC-alpha
Midostaurin
AML
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000064
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