Impact of steroid-sparing immunosuppressive agents on tumor outcome in the context of cancer immunotherapy with highlight on melanoma: a systematic literature review and meta-analysis

Impact of steroid-sparing immunosuppressive agents on tumor outcome in the context of cancer immunotherapy with highlight on melanoma: a systematic literature review and meta-analysis

BackgroundThe impact of steroid-sparing immunosuppressive agents (SSIAs) for immune-related adverse events (irAEs) on tumor outcome is not well-known. This systematic review evaluates tumor outcomes for corticosteroid (CS) monotherapy versus CS with SSIA (CS-SSIA) for irAE treatment with a focus on...

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Main Authors: Jennifer Strouse, Karmela Kimi Chan, Rachel Baccile, Gong He, Diana K. N. Louden, Mihai Giurcanu, Arohi Singh, John Rieth, Noha Abdel-Wahab, Tamiko R. Katsumoto, Namrata Singh, Sherin Rouhani, Pankti Reid
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
tumor outcome
steroid-sparing agents
disease-modifying antirheumatic drugs (DMARDs)
immune related adverse events (irAEs)
ICI toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1499478/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1499478/full

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