Substrate binding of human and bacterial type IA topoisomerase: An experimentation with AlphaFold 3.0

Substrate binding of human and bacterial type IA topoisomerase: An experimentation with AlphaFold 3.0

Advancements in biophysical techniques such as X-ray crystallography and Cryo-EM have allowed the determination of three-dimensional structures of many proteins and nucleic acids. There, however, is still a lack of 3D structures of proteins that are difficult to crystallize or proteins in complex wi...

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Bibliographic Details
Main Authors: Yasir Mamun, Ally Aguado, Ana Preza, Abhilasha Kadel, Anjani Mogallur, Briana Gonzalez, Jayleen De La Rosa, Daniel Diaz, Polina Evdokimova, Ukesh Karki, Yuk-Ching Tse-Dinh, Prem Chapagain
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
AlphaFold3
Molecular model
Topoisomerase
Substrate binding
Structure prediction
DNA supercoiling
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037025001102
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