Krüppel-like Factor 4-Deficient Cells Are Sensitive to Etoposide-Induced DNA Damage

Krüppel-like Factor 4-Deficient Cells Are Sensitive to Etoposide-Induced DNA Damage

Krüppel-like factor 4 (KLF4) is a highly conserved zinc-finger transcription factor involved in cellular processes such as development, differentiation, and cell cycle regulation. Previous studies show that mouse embryonic fibroblasts (MEFs) null for <i>Klf4</i> exhibit increased genomic...

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Bibliographic Details
Main Authors: Maxwell H. Rubinstein, Aidan Conroy, Elisabeth L. Pezzuto, Hadeel Al Qoronz, Patrick Wertimer, Engda G. Hagos
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Current Issues in Molecular Biology
Subjects:
Krüppel-like factor 4
DNA damage
genomic instability
cell cycle
DNA damage response
DNA repair
Online Access:https://www.mdpi.com/1467-3045/47/4/217
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